RNA Details
Disease Name
scleroderma systemic
Tissue
skin
RNA Symbol
mir-125b-1
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
q-PCR; immunofluorescence etc.
Target
BAK 1; BMF; BBC 3
Pathway
NA
PubMed ID
Title
Regulation of Fibroblast Apoptosis and Proliferation by MicroRNA-125b in Systemic Sclerosis
Year
2017
Function
"Our findings indicate that mir-125b is down-regulated in ssc skin and primary dermal fibroblasts. Mir-125b down-regulation increases apoptosis and decreases proliferation and alfa-sma expression in dermal fibroblasts, indicating that its compensatory, antifibrotic mechanism may be a potential novel therapeutic option."